A 2-Pyridone-Amide Inhibitor Targets the Glucose Metabolism Pathway of Chlamydia trachomatis
ABSTRACT In a screen for compounds that inhibit infectivity of the obligate intracellular pathogen Chlamydia trachomatis, we identified the 2-pyridone amide KSK120.A fluorescent KSK120 analogue was synthesized and observed to be associated with the C.trachomatis surface, suggesting that its target is bacterial.We isolated KSK120-resistant strains a